Literature Selection | Inhibiting YAP1 activity can improve acute lung injury by promoting polarization of M2 macrophages

The polarization balance of M1/M2 macrophages plays an important role in regulating the inflammatory response during acute lung injury (ALI). YAP1 is a key protein in the Hippo-YAP1 signaling pathway, involved in macrophage polarization. The research conducted by Xu Wenyan's team···

Literature selection | Targeting membrane associated protein A1 in tumor associated macrophages as a therapeutic strategy for hepatocellular carcinoma

Hepatocellular carcinoma is a common malignant tumor with limited treatment options. At present, immunotherapy has limited efficacy in liver cancer cells. Membrane associated protein A1 is a protein associated with inflammation, immunity, and tumors. However, the role of membrane···

Literature selection | Tracking the cellular interactions between circRNA miRNAaxis and DNA cascade assembly supported by Cu metal organic framework

Circular RNA (circRNA) can serve as a molecular sponge for microRNA (miRNA), forming the circRNA miRNA axis and regulating the expression of downstream proteins. Although this mechanism has been widely reported in various biological processes, there is still a lack of reliable an···

Selected Literature | Yeast Nanoparticles Driven Photodynamic Immunotherapy for Tumors

Photodynamic therapy (PDT) uses a combination of light and photosensitizers to destroy cancer cells. However, due to various factors such as insufficient ROS generation and weak induction of immune responses, PDT alone is often insufficient to trigger effective anti-tumor respons···

Literature selection | Aline regulates PKM2 nuclear accumulation and histone H3 acetylation through the TAS1R1-mTOR-DDX39B signaling pathway, promoting milk synthesis

Valine is a branched chain amino acid that plays a crucial role in the process of milk synthesis. However, the exact effect of valine on cow lactation is still a research field. Therefore, the team led by Professor Cao Yu from Jilin University isolated bovine mammary epithelial c···

Selected Literature | Biological Stimulation of Lipoproteins by Furacil Gemcitabine for Prioritizing Targeting Glioblastoma and Overcoming Radiotherapy Resistance

Radiation therapy (RT) resistance is a major challenge in the treatment of glioblastoma multiforme (GBM), which is largely related to DNA repair, poor distribution of reactive free radicals in the tumor, and limited delivery of radiosensitizers to the tumor site. Inspired by the ···

Selected Literature | Peptide TK-HR in Traditional Chinese Medicine Frog Skin Accelerates Wound Healing by Activating Neuronal Activin-1 Receptors

Wound healing is a complex process and remains a significant challenge in clinical trials due to the lack of ideal therapeutic drugs. The team led by Professor Wu Jiena from Southern Medical University tested the ability of a new peptide TK-HR identified from frog skin to heal sk···

Selected literature | Extracellular vesicles from CD271+CD56+bone marrow mesenchymal stem cell subpopulation identified by single-cell RNA sequencing promote axonal regeneration after spinal cord injury

Spinal cord injury can lead to nerve tissue damage. However, the limited regenerative ability of axons after spinal cord injury in adult mammals leads to persistent neurological dysfunction. Therefore, exploring pathways to promote axonal regeneration after spinal cord injury is ···

Literature Selection | Risk Model Guided Identification of MTDH Expression as a Marker for Iron Induced Treatment of Head and Neck Squamous Cell Carcinoma

Squamous cell carcinoma of head and neck (HNSCC) is a common malignant tumor with high mortality and incidence rate. Therefore, the team led by Professor Gao Yuzhang from Central South University established a risk scoring model using apoptosis related DNA methylation features, w···

Selected Literature | Natural Isoflavones Photoglycyrrhizin Targeting PI3K γ as Adjuvant to Enhance the Sensitivity of MDA-MB-231 to Tamoxifen and DU145 to Paclitaxel

Guanggancao Ding is a natural isoflavone with estrogen receptor agonists and significant anti-tumor activity. In addition, Guanggancao Ding has a regulatory effect on the PI3K/AKT/mTOR pathway, but its exact target is still unclear. Lin Hongyan, a teacher from Changzhou Universit···