Photodynamic therapy (PDT) uses a combination of light and photosensitizers to destroy cancer cells. However, due to various factors such as insufficient ROS generation and weak induction of immune responses, PDT alone is often insufficient to trigger effective anti-tumor responses. The team led by Professor Song Anning from Soochow University studied the use of yeast nanoparticles (YNPs) loaded with aggregation induced emission (AIE) photosensitizer QMC12 (YNP-QMC) to enhance photodynamic immunotherapy in animal models. YNPs have strong immune adjuvant effects and can significantly activate multiple APCs, reversing the immunosuppressive microenvironment in tumors and tumor draining lymph nodes (TDLN). More importantly, YNP-QMC can bind to tumor cell antigens released by dead cells after PDT. This antigen attached nanoparticle can effectively migrate to tumor draining lymph nodes and activate antigen-specific systemic anti-tumor immunity. Combined use with anti-PD-L1 can promote the elimination of primary tumors and inhibit the growth of distant tumors. Therefore, AIE photosensitizers and YNP assisted PDT strategies provide a simple way to improve PDT efficacy.
The study was published on December 19, 2023 in the international journal Nano Today, titled Yeast Nanoparticle powered Tumor Photodynamic Immunotherapy.
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Figure 1. Research published in the international journal Nano Today
Figure 2. Images in the article
Figure 3. Cell culture in this study was conducted using Opsey fetal bovine serum
https://www.sciencedirect.com/science/article/abs/pii/S1748013223003584?via%3Dihub=
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