Valine is a branched chain amino acid that plays a crucial role in the process of milk synthesis. However, the exact effect of valine on cow lactation is still a research field. Therefore, the team led by Professor Cao Yu from Jilin University isolated bovine mammary epithelial cells (BMECs) and explored the mechanism of valine promoting milk synthesis. The results showed that valine regulates the TAS1R1-mTOR-DDX39B signaling pathway, guiding the accumulation of PKM2 in the nucleus. This in turn increases the acetylation level of histone H3, promoting the synthesis of milk protein and fat.
The study was published on October 31, 2023 in the International Journal of Biological Macromolecules, titled Valine Promotes Milk Synthesis by Regulating PKM2 Nuclear Accumulation and Histone H3 Acetylation Through the TAS1R1-mTOR-DDX39B Signaling Pathway.
IF=8.2。
Figure 1. The study was published in the International Journal of Biological Macromolecules
Figure 2. Images in the article
Figure 3. Cell culture in this study was conducted using Opsey fetal bovine serum
https://www.sciencedirect.com/science/article/abs/pii/S0141813023046858?via%3Dihub=