Wound healing is a complex process and remains a significant challenge in clinical trials due to the lack of ideal therapeutic drugs. The team led by Professor Wu Jiena from Southern Medical University tested the ability of a new peptide TK-HR identified from frog skin to heal skin wounds in mice. Topical application of TK-HR at doses of 50-200 μ g/mL can significantly accelerate wound healing without causing any adverse effects on animals. In vitro and in vivo studies have demonstrated the regulatory effects of this peptide on neutrophils, macrophages, keratinocytes, and venous endothelial cells, which are involved in the inflammatory, proliferative, and remodeling stages of wound healing. Current research has found that TK-HR is an effective wound healing regulator, which can be used to treat wounds in the future, including diabetes foot ulcers and infected wounds.
The study was published on November 28, 2023 in the international journal Journal of Medical Chemistry, titled Peptide TK-HR from the Skin of Chinese Folk Medicine Frog Hoplobatrachus Rugulosus Accelerates Wow Healing via the Activation of the Neurokinin-1 Receptor.
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Figure 1. The study was published in the international journal Journal of Medicinal Chemistry
Figure 2. Images in the article
Figure 3. Cell culture in this study was conducted using Opsey fetal bovine serum
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