Special application fetal bovine serum refers to fetal bovine serum products that have been specially processed or screened for specific research or production needs. This type of serum is usually used in applications that require strict cultivation conditions, such as stem cell culture, drug development, biological product production (such as vaccines and antibodies), gene therapy research, etc.
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Serum name | Characteristics and Applications |
dialysis | Dialysis type fetal bovine serum removes some small molecular substances such as glucose, salts, and non protein binding molecules from the serum through dialysis. Dialysis treatment removes molecules with a molecular weight less than 10000 Da, which cannot remove hormones during the process, but may reduce the growth ability of some types of cells. The serum is processed at 4 ℃ and requires strict control of pH, osmotic pressure, and glucose concentration |
Ultra low IgG fetal bovine serum | Ultra low IgG fetal bovine serum (FBS) is a fetal bovine serum product that has been specially treated to reduce immunoglobulin G (IgG) levels. This type of serum is typically used for IgG sensitive applications, such as immunological research or in cell culture environments where foreign IgG interference needs to be reduced. Due to its low IgG characteristics, it can reduce non-specific binding and other interference caused by IgG, thereby improving the accuracy of experimental results. |
Heat inactivation treatment fetal bovine serum | Heat inactivation treatment is a common method of treating fetal bovine serum (FBS) in cell culture, aimed at inactivating thermally unstable components such as complement in the serum, especially enzymes that may be harmful to cells. Complement is a group of proteins present in serum that play an important role in immune responses, but their presence may sometimes have a negative impact on cell culture. The process of heat inactivation usually involves heating serum at 56 ℃ for 30 minutes. This process requires precise control of temperature and time, as excessive temperature or prolonged time can lead to the degradation of growth factors and other nutrients in serum, thereby affecting the quality of serum and the growth status of cells. |
Activated carbon treatment fetal bovine serum | Activated carbon treatment of fetal bovine serum (FBS) is a special treatment method mainly used to remove hormones, vitamins, lipids, and other small molecular substances from serum. This processing method can be used to reduce the impact of these components on specific experiments or cell cultures, especially when certain endocrine factors need to be excluded from research. |
X-ray irradiation fetal bovine serum | Radiation sterilization is an effective method of using ionizing radiation to kill microorganisms on most substances, and is internationally recognized as a terminal sterilization method for food, medical, and pharmaceutical applications. The irradiation of fetal bovine serum generally uses a dose of 25KGy cobalt-60 gamma rays, mainly to remove potential microbial contamination in the serum. In addition to normal microbial testing, the domestic bioproducts industry also requires bacteriophages to be negative in the serum. Serum used for clinical research also needs to be irradiated to ensure its safety. Fetal bovine serum is a biological product of animal origin, which has potential hazards and may carry infectious substances. Even if tested according to pharmacopoeia standards, it cannot cover all types. Therefore, irradiation of fetal bovine serum is a safety guarantee. Irradiation of fetal bovine serum may have a certain degree of impact on serum quality depending on the dosage. According to experimental data from ISIA (International Serum Industry Association), irradiation at doses less than 30KGy does not have a significant effect on fetal bovine serum, but may lead to sedimentation and slower proliferation of fetal bovine serum. |
Remove extracellular vesicles fetal bovine serum | Exosome depleted fetal bovine serum (FBS) is a specially processed serum product designed to remove or significantly reduce exosomes. Extracellular vesicles are small vesicles released by cells, with a diameter of approximately 30 to 150 nanometers. They contain molecules such as proteins, lipids, and nucleic acids, and can transmit signals between cells, participating in various physiological and pathological processes. In cell culture, the presence of extracellular vesicles may interfere with experimental results, especially when studying cell secretions, especially cell-derived extracellular vesicles. This is because the extracellular vesicles in fetal bovine serum may be confused with the extracellular vesicles of interest in the experiment, resulting in inaccurate or difficult to interpret experimental data. Therefore, in certain research fields such as basic research related to extracellular vesicles, discovery of diagnostic biomarkers, purification and functional studies of extracellular vesicles, the use of exosome free fetal bovine serum has become particularly important. |
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