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The composition of bovine serum and the differences between bovine serum and bovine serum

1. The components of bovine serum


Bovine serum is a commonly used cell culture additive, mainly derived from the blood of fetal, newborn, or adult cattle. It contains various components that can provide necessary nutrients for cells and promote cell growth and proliferation.


Table 1: Composition of bovine serum


Classification

Components

Protein class

Serum proteins (albumin, globulin), transporters (transferrin, etc.), adhesion/expansion factors, enzymes

Carbohydrates

Glucose, galactose, etc.

Fatty acids+lipids

Apolipoproteins, cholesterol, phospholipids,

ethanolamine.

growth factor

EGF, FGF, ECGF/PDGF, interleukin, TGFS.

hormone

Insulin, thyroid hormones, growth hormone

 corticosteroids, etc

Non protein nitrogen

Amino acids, purines, pyrimidines

trace element

Selenium, zinc, copper, manganese,

molybdenum,etc

There are over a thousand known components of bovine serum, and the following is a list of the main components:

图片1.png

Figure 1: Concentration of bovine serum components:

2. Differences in bovine serum


Table 2: Comparison of Differences between Bovine Serum





fetal bovine serum


Newborn bovine serum

Calf serum


Blood collection time


Serum obtained through fetal

 bovine cardiac puncture at 3-8 months

 of pregnancy in cows



Serum obtained from venous blood 

collection and isolation of healthy newborn

 cows that have not been breastfed within 14 hours 

of birth


Serum obtained from venous blood 

collection and isolation of healthy live 

cattle within 10 months of birth




Components and proportions


The components and proportions of growth promoting factors, adhesion promoting factors, hormones, and other active substances contained in 

fetal bovine serum vary. Fetal bovine serum, in particular, contains growth factors essential for embryonic development. Fetal bovine serum>newborn bovine serum>calf serum.



图片2.png

Figure 2: Comparison of some detection items between fetal bovine serum and newborn bovine serum




图片3.png

Figure 3: Comparison of specific points between fetal bovine serum and newborn bovine serum




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Figure 4: Comparison of Cell Growth Status under Different Serum and Culture Times


Adult bovine serum: 1A (12h), 2A (24h), 3A (48h); Newborn bovine serum: 1B (12h), 2B (24h), 3B (48h); Fetal bovine serum: 1C (12h), 2C (24h), 3C (48h)



图片5.png

Figure 5: Comparison of different serum cell growth curves




Note: The vertical axis represents cell proliferation; The horizontal axis represents the measurement time; Blue represents fetal bovine serum culture medium; Green represents newborn bovine serum culture medium; Red represents bovine serum culture medium. Number of cells per well in the experiment





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