There are many reasons for the appearance of flocculent substances in serum, and the most common reason is due to the denaturation of lipoproteins in serum; Fibrin (one of the coagulation proteins) also exists in serum after thawing, and is one of the main causes of flocculent substances. The production of these flocculent substances will not affect the quality of the serum itself.
If you want to remove these flocculent precipitates, you can divide the serum into sterile centrifuge tubes, centrifuge briefly at 400g centrifugal force, and then add the supernatant after centrifugation to the culture medium for filtration. We do not recommend filtering the serum directly to remove these flocs as it may clog the filtration membrane.
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